Biochem/physiol Actions
Primary TargetFree radical trap
Cell permeable: no
Reversible: no
Product does not compete with ATP.
General description
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.Floyd, R.A. 1990. FASEB J. 4, 2587.
Packaging
500 mg in Plastic ampoule
Reconstitution
Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: